Stem cell therapy for joint and spine pain

Operate, or wait and see. There's a third option.

Torn, worn, or inflamed: knee, hip, shoulder, hand and foot, plus neck, back and disc. Your imaging decides whether cell therapy is worth trying, and the physician team reads it before anyone answers.

Physician evaluating a patient's knee in a clinical exam room

Six regions, thirty conditions we screen for

We treat the whole joint: the cartilage, and the ligaments, tendons and muscles around it that drive much of the pain.

Two Celva clinicians evaluating a patient's spine on the exam table

The spine

Image-guided delivery into or beside the disc, or into the facet joint, with strict imaging screening; a herniated or degenerative disc has its own page.

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  • Facet joint arthritis
  • Degenerative disc disease
  • SI joint dysfunction
  • Chronic neck or low back pain
  • Post-laminectomy pain
See spine treatment
Physician examining a patient's knee

The knee

The joint we screen most. Cells go into the joint space under live imaging, with the needle confirmed on screen first.

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  • Osteoarthritis (moderate; end-stage case-by-case)
  • Meniscal tears
  • Patellofemoral pain
  • Post-surgical stiffness
  • Degeneration after an ACL or MCL injury
See knee treatment
Celva clinician evaluating a patient's shoulder

The shoulder

Delivery under ultrasound or fluoroscopy to the glenohumeral joint, rotator cuff tendon, or AC joint as indicated.

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  • Rotator cuff tears (partial)
  • Glenohumeral osteoarthritis
  • AC joint arthritis
  • Biceps tendinopathy
  • Labral pathology
See shoulder treatment
Physician examining a patient's hip during a clinical exam

The hip

Fluoroscopic guidance places cells precisely at the femoral head–acetabular interface.

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  • Hip osteoarthritis
  • Labral tears
  • Post-surgical hips that never settled
  • Hip impingement / FAI
  • Bursitis (recalcitrant)
See hip treatment
Celva physician examining a patient's hand and thumb joint

The hand

Ultrasound-guided injection for thumb-base (CMC) arthritis and other small-joint OA. Same image-guided precision as larger joints, smaller anatomic targets.

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  • CMC (thumb base) arthritis
  • Finger / IP joint osteoarthritis
  • Wrist osteoarthritis
  • Trigger finger, early stage (case by case)
  • Inflammatory hand pain
See hand treatment
Celva physician examining a patient's foot for plantar and joint pain

The foot

Ankle arthritis is the main indication. Fluoroscopy or ultrasound guides delivery to the joint, and ultrasound to the plantar fascia, tendons, and peri-bony sites.

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  • Ankle osteoarthritis
  • Plantar fasciitis
  • Achilles tendinopathy / tendinosis
  • Posterior tibial tendon dysfunction
  • Calcific deposits / heel spurs
See foot treatment

Who's a fit, and who isn't

A significant share of inquiries are declined by the physician team. Not because we can't help, but because cell therapy isn't the right tool for every problem.

You are a strong fit if:

  • You have recent imaging (MRI or weight-bearing X-ray), or will let us take it on site.
  • Your pain maps to a joint or spinal level we can target.
  • Conservative care has plateaued: PT, NSAIDs, cortisone, hyaluronic.
  • Surgery is on the table (replacement, arthroscopy, discectomy) and you want to delay it.
  • You have bone-on-bone (end-stage) arthritis and want to delay joint replacement, with realistic expectations of a lower response than moderate wear.
  • Your BMI, medications and health allow an image-guided procedure.

We wouldn't recommend it if:

  • Active joint infection, uncontrolled autoimmune disease, or recent cancer.
  • In chemotherapy or radiation, or inside the post-cancer surveillance window.
  • The problem needs hardware: unstable ligament, fracture, severe deformity.
  • Pregnant or immunocompromised.
  • You want one and done, without the rehab and follow-up that make it work.

What changes at the injection site

Chronic damage settles into a state that prevents healing. The injection puts cells directly into it, and the same-session IV sends more through the bloodstream.

From your imaging to month 12

No two joint cases get the same recipe. Which cells, in what dose, by which route is decided after the physician team reads your imaging.

Call, records & review

A 15-minute call with a patient coordinator, who gathers whatever records you have, including the imaging CD no computer in your house will open. The physician team reviews them, and you get a written answer and an itemized quote. No MRI or bloodwork is required to start: imaging can be done at the hospital, and labs only when the physician team asks for them.

Image-guided delivery

Bone-marrow and umbilical-cord MSCs, chondrocytes where cartilage needs support, at a dose sized to the joint and your case. Drawn into a 5cc syringe and injected under live fluoroscopic or ultrasound guidance, position confirmed before release. 15 to 30 minutes, under local anesthetic, with twilight sedation available if you want it (no general). One or two companions in the room with you.

Systemic IV infusion

A second allogeneic MSC dose, delivered IV in the infusion suite, monitored. About 45 minutes. The IV and the injection are designed to work together.

Most patients home the same day

Monitored rest, then discharge instructions and a Celva driver back to San Diego once the attending physician has authorized it. You go home the same day, about 4 hours after you arrived.

Protect the joint, then build back

Expect mild soreness at the injection site for 24 to 72 hours. Knee, hip, ankle and foot: stay off the joint with very limited activity for the first 7 to 10 days. Shoulder and hand: light daily use is fine while you protect the joint. Spine: about a week of soreness, then normal activity. Physical therapy is recommended after the first 7 to 10 days; outside it, avoid loading the joint for 4 to 6 weeks. Running and impact sport wait until weeks 8 to 12. You get the written protocol before you fly home.

Check-ins, then once a year

Follow-up calls from your patient coordinator or aftercare specialist at 1 week, then at 1, 3 and 6 months, then once a year, by phone or video. A physician joins when needed. One session; whether a second treatment makes sense is decided at your follow-up reviews.

Patients who stood where you are

Celva patients, in their own words. No stock footage and no scripts. Individual results vary.

Jon C., 42 · Back pain
Kathie M., 67 · Knee pain
Pete W., 68 · Rheumatoid arthritis
Sally W., 64 · Back pain
Scott M., 68 · Degenerative disc

Watch more patient stories

What people ask about joint cases

If I'm scheduled for a knee replacement, is it too late?
Imaging tells us. Moderate wear is often a strong candidate, even if surgery has been recommended. For end-stage, bone-on-bone joints with subchondral loss, we'll still consider treating you if you want to delay replacement, just with a frank conversation about lower expected response. Send your patient coordinator your most recent imaging and the physician team will read it.
Is it image-guided? Can it miss the target?
Every intra-articular delivery is performed under live fluoroscopy or ultrasound by an attending physician. Needle position is confirmed before cells are released. "Blind" injection (common at non-hospital clinics) is never used for joint work at Celva.
Will it regrow cartilage?
We won't tell you that. MSCs are paracrine signalers. They release factors that modulate inflammation and support the body's own repair machinery. In joints, the typical observation is reduced pain, improved function, and slowed progression. Some patients show cartilage preservation on follow-up imaging. True regrowth is rare, and we don't lead with it.
How is this different from PRP or a cortisone shot?
PRP concentrates your own platelets and growth factors. Cortisone is an anti-inflammatory steroid. MSC therapy introduces living, screened, expanded mesenchymal stem cells that signal for a longer therapeutic window. Three different tools. Many patients arrive having tried PRP and cortisone first, which is usually the right order.

See if you're a candidate

Book a call with a patient coordinator and send your imaging. The physician team reads it and tells you plainly whether cell therapy is the right next step. If it isn't, they say so.

Book a call →